Peptide Bond Formation
Elongation of the polypeptide chain occurs on the
ribosome. The growing chain attached to a tRNA occupies the peptidyl, P, site
of the ribosome (Fig. 7.14). Alongside is another charged tRNA, also with its
anticodon base paired to a codon on the mRNA. This second site is termed the
acceptor, or A site since the amino acid here will act as an acceptor as the
peptide chain is transferred to it. This transfer is catalyzed by the peptidyl
transferase activity of the large subunit. Although this activity is stimulated
by ribosomal proteins, in vitro it
can be catalyzed by the ribosomal RNA itself. This step does not require an
external source of energy like GTP.
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