Nephrotic syndrome
This is defined as a combination
of:
·
Heavy
proteinuria (urinary protein to creatinine ratio >200mg/mmol).
·
Hypoalbuminaemia
(albumin <25g/L).
·
Oedema.
·
Hyperlipidaemia.
The incidence is approximately 2/100,000
children with a peak age of onset in children aged <6yrs. Boys are more
commonly affected than girls (2:1) and there is an increased frequency in
certain ethnic groups, e.g. Indian subcontinent. Nephrotic syndrome can be
either primary or secondary
·
Congenital.
·
Infantile.
·
Minimal change disease (MCD): commonest (85%).
·
Focal
segmental glomerulosclerosis (FSGS; 10%).
·
Membranoproliferative
glomerulonephritis (MPGN; 5%).
·
Membranous
glomerulonephritis (MGN).
Nephrotic syndrome can be
clinically classified as being either steroid-sensitive (SS), steroid dependent
or steroid-resistant (SR). The majority of MCD is SS.
·
MCD
(SS), >95%.
·
FSGS
(SS), 20%.
·
MPGN
(SS), 55%.
Most children present with insidious
onset of oedema, which is initially perorbital, but becoming generalized with
pitting oedema. Perorbital oe-dema is often most noticeable in morning on
rising. Ascites and pleural effusions may subsequently develop.
This should establish the extent
of dependent oedema, e.g. facial, ankle, scrotal, etc. Assessment should also
include:
·
Height
and weight (compare with previous/recent measurements).
·
BP.
Peripheral perfusion.
·Urinalysis:
protein +++.
·Microscopy:
haematuria/casts (suggest causes
other than MCD).
·Na+: If <10mmol/L suggests
hypovolaemia. (Note: If patient has received diuretics this is not
accurate.)
·Culture.
·Protein:creatinine ratio (early
morning urine specimen).
·Serum albumin (reduced, <25g/L).
·U&E/creatinine (decreased
sodium and total calcium—with normal ionized calcium).
·C3/C4 (if decreased suggests not
MCD).
·Consider ANF, ASOT, ANCA,
immunoglobulins if mixed nephritic/ nephrotic picture.
·Lipids:
total cholesterol/low density
lipoprotein (LDL)/very low density lipoprotein
(VLDL).
·Haemoglobin may be increased or
decreased depending on plasma volume.
·Varicella zoster immunity status.
Patients should be admitted,
particularly if this is their first episode or if there are concerns regarding
complications. Management is initially aimed at fluid restriction and
prevention of hypovolaemia. A trial of oral steroid therapy to induce remission
is also started. Prophylaxis against bacterial infection (particularly
pneumococcal) is also required.
·Treat hypovolaemia if present but
albumin infusion is not routine.
·Fluid restriction to
800–1000mL/24hr.
·Diuretics if very oedematous and
no evidence of hypovolaemia. Furosemide/spironolactone.
·Steroid
therapy:
o
oral
prednisolone 60mg/m2/day for 4wks;
o
followed
by 40mg/m2/alternate days for 4wks; then
o
stop—slow wean over next 4mths with
slow taper, but need to consider
side-effects of steroids.
·Diet (no added salt and healthy
eating—not high protein).
·Prophylactic antibiotics (oral
penicillin V) until oedema-free.
·Immunize with pneumococcal
vaccine.
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