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Chapter: Paediatrics: Growth and puberty

Paediatrics: Micropenis

Micropenis is often an incidental finding on newborn examination.

Micropenis

 

Micropenis is often an incidental finding on newborn examination.

An intact hypothalamic–pituitary–gonadal axis is required for the forma-tion of a normal-sized phallus and for descent of the testis. Both GH and the gonadotrophins are required for phallic growth.

 

The finding of micropenis warrants assessment of hypothalamic–pitu-itary function and exclusion of both GH deficiency and HH. Micropenis may also be part of a syndrome causing ambiguous genitalia.

 

Evaluation

 

Penile size

 

·Measured from pubic tubercle to tip of stretched penis in a term baby.

 

·Normal size at birth is usually >3cm.

 

·Micropenis <2.2–2.5cm (varies with ethnicity).

 

General examination

 

·Dysmorphism.

 

·Midline craniofacial defects.

 

Ophthalmic examination

 

Optic nerve hypoplasia/septo-optic dysplasia.

 

Investigations

 

·US of head for midline defects.

 

·MRI head.

 

·Anterior pituitary hormone levels (basal and stimulated): ACTH and cortisol; GH (IGF-I, IGFBP3); LH and FSH; TSH and fT4.

 

·Karyotype.

 

Management

 

Referral to a paediatric urologist is often required. If severe micropenis is present a decision regarding sex assignment will be needed.

 

Treatment with a short course of IM testosterone or topical application of dihydrotestosterone cream may stimulate penile growth and improve appearances.

 

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