Nimesulide
Nimesulide
belongs to the sulfonanilide class of NSAIDs, and has rapidly gained in
popularity as an anti-inflammatory drug with analgesic-antipyretic properties.
It is said to have a good safety profile, and overdoses have so far rarely been
reported. However, a few rare cases document fulminant hepatic failure in
patients who were taking nimesulide regularly. These patients had increasing
jaundice over a 7 to 10-day period, in addition to confusion, nausea, and
vomiting. Despite liver transplantation, some patients died due to multi-organ
failure. Today there are emerging concerns about the real safety profile of
nimesulide.
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