Nervous Control of
Gastrointestinal Blood Flow
Stimulation of the parasympathetic nerves going to the stomach and lower colon increases local blood flow atthe same time that it
increases glandular secretion. This increased flow probably results secondarily
from the increased glandular activity and not as a direct effect of the nervous
stimulation.
Sympathetic
stimulation, by contrast, has a direct effect on essentially all the
gastrointestinal tract to cause intense vasoconstriction of the arterioles with
greatly decreased blood flow. After a few minutes of this vasoconstriction, the
flow often returns almost to normal by means of a mechanism called
“autoregula-tory escape.” That is, the local metabolic vasodilator mechanisms
that are elicited by ischemia become pre-potent over the sympathetic
vasoconstriction and, therefore, redilate the arterioles, thus causing return
of necessary nutrient blood flow to the gastrointestinal glands and muscle.
Importance of Nervous Depression of
Gastrointestinal Blood Flow When Other Parts of the Body Need Extra Blood Flow.
Amajor
value of sympathetic vasoconstriction in the gut is that it allows shut-off of
gastrointestinal and other splanchnic blood flow for short periods of time
during heavy exercise, when increased flow is needed by the skeletal muscle and
heart. Also, in circulatory shock, when all the body’s vital tissues are in
danger of cel-lular death for lack of blood flow—especially the brain and the
heart—sympathetic stimulation can decrease splanchnic blood flow to very little
for many hours.
Sympathetic
stimulation also causes strong vaso-constriction of the large-volume intestinal and mesen-teric veins. This decreases the volume of these veins,thereby
displacing large amounts of blood into other parts of the circulation. In
hemorrhagic shock or other states of low blood volume, this mechanism can
provide as much as 200 to 400 milliliters of extra blood to sustain the general
circulation.
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