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Chapter: Basic & Clinical Pharmacology : Tetracyclines, Macrolides,Clindamycin,Chloramphenicol,Streptogramins,& Oxazolidinones

Macrolides

The macrolides are a group of closely related compounds characterized by a macrocyclic lactone ring (usually containing 14 or 16 atoms) to which deoxy sugars are attached.

MACROLIDES

The macrolides are a group of closely related compounds charac-terized by a macrocyclic lactone ring (usually containing 14 or 16 atoms) to which deoxy sugars are attached. The prototype drug, erythromycin, which consists of two sugar moieties attached to a 14-atom lactone ring, was obtained in 1952 from Streptomyceserythreus. Clarithromycin and azithromycin are semisyntheticderivatives of erythromycin.



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Basic & Clinical Pharmacology : Tetracyclines, Macrolides,Clindamycin,Chloramphenicol,Streptogramins,& Oxazolidinones : Macrolides |


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