MACROLIDES
The
macrolides are a group of closely related compounds charac-terized by a
macrocyclic lactone ring (usually containing 14 or 16 atoms) to which deoxy
sugars are attached. The prototype drug, erythromycin, which consists of two
sugar moieties attached to a 14-atom lactone ring, was obtained in 1952 from Streptomyceserythreus. Clarithromycin
and azithromycin are semisyntheticderivatives of erythromycin.
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