Lungs
General Comments
Pathologists
are routinely called on to process a diverse spectrum of lung specimens,
ranging in size and complexity from minute biopsies to pneumonectomies. Despite
this diversity, these specimens can be systematically approached by keeping in
mind the five basic components of the lung specimen: the airways, the lung
paren-chyma, the pleura, the vessels, and the lymph nodes.
Before
beginning the dissection, be sure to ask yourself two questions: First, does
the pathology need to be revealed immediately? For example, if an infection is
suspected, cultures may have to be taken from fresh tissues in a sterile
fashion. Likewise, in the case of a suspected neoplasm, frozen section
evaluation may be required to es-tablish a diagnosis or to assess resection
mar-gins, and sampling of fresh tissue may be needed for ancillary diagnostic
studies, such as electron microscopy. Next, ask which method of dissec-tion
will most effectively reveal the pathologic process and best demonstrate the
relationship of the disease to the surrounding lung and pleura. There is more
than one way to dissect a lung, and the method of sectioning is often dictated
by the type of specimen, the suspected nature of the pathologic process, and
the size and location of the pathologic process. Clearly, the more clinical
information that is available, including radio-graphic findings, the more
effectively these ques-tions can be answered. Finally, keep in mind that a
wealth of information can be obtained simply by palpating the intact specimen.
Even small focal lesions can be appreciated by palpation, and this fast and
easy method of examination should become a routine part of the initial
evaluation of any lung resection.
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