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Chapter: Medicine and surgery: Gastrointestinal system

Ischaemic colitis - Vascular disease of the bowel

Ischaemia of the colon due to interruption of its blood supply. - Definition, Incidence, Aetiology, Pathophysiology, Clinical features, Complications, Investigations, Management, Prognosis.

Ischaemic colitis

 

Definition

 

Ischaemia of the colon due to interruption of its blood supply.

 

Aetiology

 

In most cases the underlying cause is thrombosis of the inferior mesenteric artery, embolisation of mural thrombus in atrial fibrillation, or non-occlusive infarction.

 

Pathophysiology

 

In around half the ischaemia is transient with damage confined to the mucosa and submucosa. The splenic flexure is most often affected due to the territories of the arteries supplying the bowel. If the blood supply is not restored, ischaemia progresses to gangrenous ischaemic colitis. The presentation and treatment is as for acute intestinal failure.

 

Clinical features

 

The patient presents with lower abdominal pain, nausea, vomiting and bloody diarrhoea. There is lower abdominal tenderness and guarding in the lower abdomen.


Microscopy

There is ischaemic loss of mucosa, ulceration and later healing with oedema and inflammatory infiltrate.


Complications

 

Ischaemic strictures may result from scarring at the splenic flexure or sigmoid colon. These are confirmed on barium studies and require resection.

 

Investigations

 

A barium enema can be used to show oedema or mucosal sloughing. Bleeding into the bowel wall produces a thumb print appearance. Mesenteric angiography will demonstrate the stenosis or occlusion.

 

Management

 

The condition generally is selflimiting within a few days with uncomplicated cases managed conservatively.

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