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Chapter: Clinical Anesthesiology: Clinical Pharmacology: Intravenous Anesthetics

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Intravenous Anesthetics: Fospropofol

Fospropofol is a water-soluble prodrug that is metabolized in vivo to propofol, phosphate, and formaldehyde.

FOSPROPOFOL

Fospropofol is a water-soluble prodrug that is metabolized in vivo to propofol, phosphate, and formaldehyde. It has been released in the United States and other countries based on studies show-ing that it produces more complete amnesia and better conscious sedation for endoscopy than mid-azolam plus fentanyl. It has a slower onset and slower recovery than propofol, offering little reason for anesthesiologists to use fospropofol in place of propofol. The place (if any) of fospropofol relative to other competing agents has not yet been established in clinical practice.

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