Chapter: Pathology: Genetic Disorders
Genomic Imprinting
Genomic imprinting refers to differential expression of genes based on chromo-somal inheritance from maternal versus paternal origin.
GENOMIC IMPRINTING
Genomic imprinting refers
to differential expression of genes based on chromo-somal inheritance from
maternal versus paternal origin.
·
In Prader-Willi syndrome,
microdeletion on paternal chromosome 15 {del(15) (q11;q13)}
causes intellectual disability, obesity, hypogonadism, and hypotonia.
·
In Angelman syndrome,
microdeletion on maternal chromosome 15 {del(15) (q11;q13)} causes intellectual
disability, seizures, ataxia, and inappropriate laughter.
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Pathology: Genetic Disorders : Genomic Imprinting |
Related Topics
Pathology: Genetic Disorders