Clotrimazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum fungistatic imidazole drug used in the topical treatment of oral, skin, and vaginal infections with C. albicans. It is also employed in the treatment of infections with cutaneous dermatophytes.
Topical use results in therapeutic drug concentra-tions in the epidermis and mucous membranes; less than 10% of the drug is systemically absorbed. Al-though clotrimazole is generally well tolerated, local ab-dominal cramping, increased urination, and transient liver enzyme elevations have been reported.
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